Amino Pure Canada is a proudly Canadian source for premium peptides like BPC-157, TB-500, CJC-1295, NAD+ and GHK-Cu. HPLC-tested and ship fast from within Canada.
TB-500
From
C$89.99
C$71.99
For research purposes only
TB-500 Peptide
Scientific Overview and Benefits
TB-500, the synthetic analog of Thymosin Beta-4 (Tβ4), is a 43-amino-acid peptide derived from the TMSB4X gene. It has been studied for its angiogenic, regenerative, and anti-inflammatory properties, with potential applications in wound healing, neurological recovery, and tissue repair.
Mechanism of Action
TB-500 interacts with actin-binding sites, influencing cell migration and cytoskeletal remodeling—critical for tissue regeneration. It modulates G-actin sequestration, increasing availability for cellular motility, which may impact wound healing, tissue repair, and metastatic potential.
Biological Significance
Detected in blood plasma and wound exudates, TB-500 may stimulate angiogenesis, enhance collagen deposition, and regulate ATP synthase activity, influencing intracellular and extracellular healing processes.
Research Highlights
Wound Healing: Studies indicate accelerated re-epithelialization and wound contraction, with enhanced vascularization and collagen synthesis.
- Cardiac Regeneration: Preliminary research suggests TB-500 may reduce ventricular hypertrophy, promote angiogenesis, and enhance cardiomyocyte resilience under hypoxic conditions.
- Anti-Inflammatory Action: Modulates microRNA-146a, potentially inhibiting pro-inflammatory pathways via IRAK1 and TRAF6 regulation.
- Hair Follicle Growth: Investigations show TB-500 may increase hair shaft density through altered mRNA and protein expression in dermal tissue.
Quantity
Chemical Makeup
-Molecular Formula: C₂₁₂H₃₅₀N₅₆O₇₈S
- Molecular Weight: 4963 g/mol
- Alternative Name: Thymosin Beta-4
References
Keinman HK, Sosne G. Thymosin β4 Promotes Dermal Healing. Vitam Horm. 2016;102:251-75. doi: 10.1016/bs.vh.2016.04.005. Epub 2016 May 24.
Ho EN, Kwok WH, Lau MY, Wong AS, Wan TS, Lam KK, Schiff PJ, Stewart BD. Doping control analysis of TB-500, a synthetic version of an active region of thymosin β₄, in equine urine and plasma by liquid chromatography-mass spectrometry. J Chromatogr A. 2012 Nov 23;1265:57-69. doi: 10.1016/j.chroma.2012.09.043. Epub 2012 Sep 23.
Gurtner GC, Werner S, Barrandon Y, Longaker MT. Wound repair and regeneration. Nature. 2008 May 15;453(7193):314-21. doi: 10.1038/nature07039. PMID: 18480812.
Santra, M., Zhang, Z. G., Yang, J., Santra, S., Santra, S., Chopp, M., & Morris, D. C. (2014). Thymosin β4 up-regulation of microRNA-146a promotes oligodendrocyte differentiation and suppression of the Toll-like proinflammatory pathway. The Journal of biological chemistry, 289(28), 19508–19518. https://doi.org/10.1074/jbc.M113.529966
Katherine M. Malinda et.al, Thymosin β4 Accelerates Wound Healing, Journal of Investigative Dermatology, Volume 113, Issue 3, 1999, Pages 364-368, ISSN 0022-202X.
Treadwell T, Kleinman HK, Crockford D, Hardy MA, Guarnera GT, Goldstein AL. The regenerative peptide thymosin β4 accelerates the rate of dermal healing in preclinical animal models and in patients. Ann N Y Acad Sci. 2012 Oct.
Wei C, Kim IK, Li L, Wu L, Gupta S. Thymosin Beta 4 protects mice from monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy. PLoS One. 2014 Nov 20;9(11):e110598.
Srivastava, D., Ieda, M., Fu, J., & Qian, L. (2012). Cardiac repair with thymosin β4 and cardiac reprogramming factors. Annals of the New York Academy of Sciences, 1270, 66–72. https://doi.org/10.1111/j.1749-6632.2012.06696.x
Bock-Marquette, I., Saxena, A., White, M. D., Dimaio, J. M., & Srivastava, D. (2004). Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature, 432(7016), 466–472. https://doi.org/10.1038/nature03000
Gao, Xy., Hou, F., Zhang, Zp. et al. Role of thymosin beta 4 in hair growth. Mol Genet Genomics 291, 1639–1646 (2016).
Huff, T., Müller, C. S., Otto, A. M., Netzker, R., & Hannappel, E. (2001). beta-Thymosins, small acidic peptides with multiple functions. The international journal of biochemistry & cell biology, 33(3), 205–220. https://doi.org/10.1016/s1357-2725(00)00087-x
Freeman, K. W., Bowman, B. R., & Zetter, B. R. (2011). Regenerative protein thymosin beta-4 is a novel regulator of purinergic signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 25(3), 907–915. https://doi.org/10.1096/fj.10-169417
Lv, S., Cai, H., Xu, Y., Dai, J., Rong, X., & Zheng, L. (2020). Thymosin‑β 4 induces angiogenesis in critical limb ischemia mice via regulating Notch/NF‑κB pathway. International journal of molecular medicine, 46(4), 1347–1358. https://doi.org/10.3892/ijmm.2020.4701
Sosne, G., Qiu, P., & Kurpakus-Wheater, M. (2007). Thymosin beta 4: A novel corneal wound healing and anti-inflammatory agent. Clinical ophthalmology (Auckland, N.Z.), 1(3), 201–207.
Spray Atomizer
TB-500 is supplied in a spray atomizer with a vial of sterile water containing 0.3% potassium sorbate as a preservative. Add the sterile water to the dispenser before use. Refrigerate after reconstitution.
Available sizes:
- 5 ml dispenser: 5 mg, ~30 pumps (166 mcg/pump)
- 10 ml dispenser: 10 mg, ~60 pumps (166 mcg/pump)
- 20 ml dispenser: 20 mg, ~60 pumps (333 mcg/pump
Reviews
I’ve tried TB-500 from other suppliers before, but this one offers the same great results at a more affordable price. The quality is consistent, and I’ve had noticeable improvements in recovery and inflammation. Definitely sticking with this source moving forward!
I’ve been using TB-500 and have observed excellent regenerative properties. It appears to support faster recovery from soft tissue strain and inflammation, especially when combined with BPC-157. The purity and consistency from this source have been reliable.
Bought this along with BPC-157 — quality is top-notch. Had a couple of questions and customer service replied super fast. Really happy with the whole experience!
Livraison rapide et bien emballée. Je commence à voir une amélioration au niveau de la récupération musculaire. Très bon service client, merci AminoPureCanada !
Just received my order — the purchase was smooth, the price was fair, and shipping was immediate. Looking forward to testing the results and will update soon!
TB-500 worked really well for me, especially in combination with BPC-157. Noticeable improvement and faster recovery. Very satisfied!
These capsules really help with recovery. My joint pain is reduced, and I feel less sore after workouts. Great quality and easy to take!
Ordered TB-500 capsules — arrived quickly and in great packaging. Haven’t tested the quality yet, but everything looks good so far!
Fast delivery, well packaged. I’ve started noticing better recovery and less inflammation. Excellent service from AminoPureCanada!
TB-500 is a game changer. Joints feel smoother, workouts don’t wreck me anymore. It’s like my body’s healing on fast-forward.