TB-500
From
$89.99
$55.99
Buy TB-500 Peptide in Canada – Research-Grade Thymosin Beta-4 Analog
For Research Use Only - TB-500 is a synthetic analog of Thymosin Beta-4 (Tβ4), consisting of 43 amino acids encoded by the TMSB4X gene. It has been widely studied for its angiogenic, regenerative, and anti-inflammatory properties, making it a peptide of interest in research on wound healing, tissue repair, and neurological recovery.
Mechanism of Action
TB-500 interacts with actin-binding sites, influencing cell migration and cytoskeletal remodeling — key processes for tissue regeneration. By modulating G-actin sequestration, TB-500 helps increase cellular motility, which may play a role in wound repair, muscle recovery, and vascular health.
Research Highlights
Wound Healing: Shown to accelerate re-epithelialization and wound contraction, with improved vascularization and collagen synthesis.
Cardiac Regeneration: Preliminary research suggests TB-500 may reduce ventricular hypertrophy, promote angiogenesis, and enhance cardiomyocyte resilience under hypoxic conditions.
Anti-Inflammatory Action: Modulates microRNA-146a, potentially inhibiting pro-inflammatory pathways (IRAK1 and TRAF6 regulation).
Hair Follicle Growth: Investigations indicate TB-500 may stimulate hair shaft density by altering dermal protein and mRNA expression.
Trusted Quality
At Amino Pure Canada, we supply HPLC-tested peptides backed by Certificates of Analysis (COAs). With fast, nationwide shipping, TB-500 is provided as a research-grade peptide only for laboratory and scientific studies.
Important Notice – Research Use Only All products offered are strictly intended for laboratory and scientific research purposes only. They are not approved by Health Canada and must not be used for human or veterinary consumption, therapeutic applications, or self-administration under any circumstances. Descriptions provided, including potential biological actions or benefits, are based on preliminary scientific research. These findings are experimental in nature and should not be interpreted as medical claims, therapeutic recommendations, or evidence of safety or efficacy. Regulatory Disclaimer Unauthorized health products have not been approved by Health Canada, which means they have not been assessed for safety, efficacy, or quality. Use of such products outside of controlled research environments may pose serious health risks.
Quantity
Chemical Makeup
-Molecular Formula: C₂₁₂H₃₅₀N₅₆O₇₈S
- Molecular Weight: 4963 g/mol
- Alternative Name: Thymosin Beta-4
References
Keinman HK, Sosne G. Thymosin β4 Promotes Dermal Healing. Vitam Horm. 2016;102:251-75. doi: 10.1016/bs.vh.2016.04.005. Epub 2016 May 24.
Ho EN, Kwok WH, Lau MY, Wong AS, Wan TS, Lam KK, Schiff PJ, Stewart BD. Doping control analysis of TB-500, a synthetic version of an active region of thymosin β₄, in equine urine and plasma by liquid chromatography-mass spectrometry. J Chromatogr A. 2012 Nov 23;1265:57-69. doi: 10.1016/j.chroma.2012.09.043. Epub 2012 Sep 23.
Gurtner GC, Werner S, Barrandon Y, Longaker MT. Wound repair and regeneration. Nature. 2008 May 15;453(7193):314-21. doi: 10.1038/nature07039. PMID: 18480812.
Santra, M., Zhang, Z. G., Yang, J., Santra, S., Santra, S., Chopp, M., & Morris, D. C. (2014). Thymosin β4 up-regulation of microRNA-146a promotes oligodendrocyte differentiation and suppression of the Toll-like proinflammatory pathway. The Journal of biological chemistry, 289(28), 19508–19518. https://doi.org/10.1074/jbc.M113.529966
Katherine M. Malinda et.al, Thymosin β4 Accelerates Wound Healing, Journal of Investigative Dermatology, Volume 113, Issue 3, 1999, Pages 364-368, ISSN 0022-202X.
Treadwell T, Kleinman HK, Crockford D, Hardy MA, Guarnera GT, Goldstein AL. The regenerative peptide thymosin β4 accelerates the rate of dermal healing in preclinical animal models and in patients. Ann N Y Acad Sci. 2012 Oct.
Wei C, Kim IK, Li L, Wu L, Gupta S. Thymosin Beta 4 protects mice from monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy. PLoS One. 2014 Nov 20;9(11):e110598.
Srivastava, D., Ieda, M., Fu, J., & Qian, L. (2012). Cardiac repair with thymosin β4 and cardiac reprogramming factors. Annals of the New York Academy of Sciences, 1270, 66–72. https://doi.org/10.1111/j.1749-6632.2012.06696.x
Bock-Marquette, I., Saxena, A., White, M. D., Dimaio, J. M., & Srivastava, D. (2004). Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature, 432(7016), 466–472. https://doi.org/10.1038/nature03000
Gao, Xy., Hou, F., Zhang, Zp. et al. Role of thymosin beta 4 in hair growth. Mol Genet Genomics 291, 1639–1646 (2016).
Huff, T., Müller, C. S., Otto, A. M., Netzker, R., & Hannappel, E. (2001). beta-Thymosins, small acidic peptides with multiple functions. The international journal of biochemistry & cell biology, 33(3), 205–220. https://doi.org/10.1016/s1357-2725(00)00087-x
Freeman, K. W., Bowman, B. R., & Zetter, B. R. (2011). Regenerative protein thymosin beta-4 is a novel regulator of purinergic signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 25(3), 907–915. https://doi.org/10.1096/fj.10-169417
Lv, S., Cai, H., Xu, Y., Dai, J., Rong, X., & Zheng, L. (2020). Thymosin‑β 4 induces angiogenesis in critical limb ischemia mice via regulating Notch/NF‑κB pathway. International journal of molecular medicine, 46(4), 1347–1358. https://doi.org/10.3892/ijmm.2020.4701
Sosne, G., Qiu, P., & Kurpakus-Wheater, M. (2007). Thymosin beta 4: A novel corneal wound healing and anti-inflammatory agent. Clinical ophthalmology (Auckland, N.Z.), 1(3), 201–207.
Spray Atomizer
TB-500 is supplied in a spray atomizer with a vial of sterile water containing 0.3% potassium sorbate as a preservative. Add the sterile water to the dispenser before use. Refrigerate after reconstitution.
Available sizes:
- 5 ml dispenser: 5 mg, ~30 pumps (166 mcg/pump)
- 10 ml dispenser: 10 mg, ~60 pumps (166 mcg/pump)
- 20 ml dispenser: 20 mg, ~60 pumps (333 mcg/pump
Certificates of Analysis (COA)
TB-500 from Amino Pure Canada is backed by a verified Certificate of Analysis (COA), confirming HPLC-tested purity above 98% for Canadian researchers.
Why Amino Pure Canada for Peptides
At Amino Pure Canada, we supply HPLC-tested peptides in Canada — including BPC-157, TB-500, and NAD+. Backed by COAs and fast Canada-wide shipping, we’re a trusted national source for peptides Canada can rely on.
