SLU‑PP‑332

SLU-PP-32 is peptide in Canada 4-Hydroxy-N-[(Z)-naphthalen-2-ylmethylideneamino

SLU‑PP‑332 is an experimental small‑molecule agonist of the estrogen‑related receptor (ERR) family, with highest potency toward ERRα. ERRs are orphan nuclear receptors that regulate cellular energy metabolism, mitochondrial biogenesis, and oxidative capacity in metabolically active tissues.

At the molecular level, SLU‑PP‑332 demonstrates high binding affinity with reported EC₅₀ values of approximately 98 nM (ERRα), 230 nM (ERRβ), and 430 nM (ERRγ). Through ERR activation, the compound enhances transcriptional programs associated with fatty‑acid oxidation, mitochondrial respiration, and ATP production.

In preclinical murine models, SLU‑PP‑332 functions as an “exercise‑mimetic” compound—upregulating metabolic pathways typically induced by endurance activity, without requiring increased physical exertion. Current investigations focus on its potential roles in metabolic dysfunction, energy‑balance regulation, and mitochondrial performance.

SLU‑PP‑332 is not approved for human or veterinary use. It is supplied strictly for laboratory research applications.

Key Research Benefits

1. Potent Activation of ERR Signaling

• Engages ERRα with nanomolar affinity, driving transcription of genes involved in energy expenditure, fatty‑acid oxidation, and mitochondrial biogenesis.
• Useful for studying nuclear‑receptor signaling pathways and metabolic regulation.

2. Exercise‑Mimetic Metabolic Effects

• In animal studies, SLU‑PP‑332 increases mitochondrial activity in skeletal muscle and adipose tissue.
• Enables researchers to model exercise‑induced metabolic adaptations without physical activity variables.

3. Modulation of Body‑Weight and Adiposity in Preclinical Models

• Obese mice exhibited significantly reduced fat accumulation (up to ten‑fold less) and approximately 12% lower body weight.
• Supports research into mechanisms of energy balance, lipid metabolism, and obesity biology.

4. Broad Therapeutic Research Potential

• Under investigation for roles in:
  • Obesity and metabolic syndrome
  • Type 2 diabetes
  • Non‑alcoholic fatty liver disease (NAFLD)
  • Potential renal‑protective pathways
• Provides a versatile tool for studying metabolic disease mechanisms.

5. Well‑Characterized Molecular Profile

• Defined ERR subtype affinities (α, β, γ) allow precise receptor‑selectivity studies.
• Suitable for mechanistic work in mitochondrial physiology, oxidative metabolism, and nuclear‑receptor pharmacology.

Trusted Quality
At Amino Pure Canada, we supply HPLC-tested peptides backed by Certificates of Analysis (COAs). With fast, nationwide shipping, SL-PP=32 is provided as a research-grade peptide only for laboratory and scientific studies.

Strictly for research Purposes