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Semax
C$56.99
For Research Purpose Only
Mechanism of Action
Semax is a synthetic analog of ACTH (4-7) with modifications that enhance stability, bioavailability, and blood-brain barrier (BBB) permeability. The Pro-Gly-Pro (PGP) sequence increases lipophilicity, promoting passive diffusion and receptor-mediated transport. Acetylation protects against enzymatic degradation, extending half-life and efficacy.
Key Benefits
- Cognitive Enhancement – May improve memory, focus, and learning capacity through modulation of dopamine and brain-derived neurotrophic factor (BDNF).
- Neuroprotection – Potentially stabilizes neuronal function, reducing oxidative stress and preventing neural damage.
- Mood Regulation – Modulates dopaminergic and serotonergic pathways, possibly alleviating anxiety and stress-related symptoms.
- Pain and Stress Management – Inhibits enkephalin degradation, which may enhance natural pain relief and stress adaptation.
- Immune Support – Suggested to modulate gene expression, influencing chemokine and immunoglobulin levels for improved vascular and immune function.
Quantity
Molecular Makeup
Molecular Formula: C39H54N10O10S
Molecular Weight: 854.99 g/mol
Other Known Titles: ACTH (4-7)PGP, HY-P1146
Research Insights
Semax is a synthetic ACTH-derived peptide with neuroprotective, nootropic, and vascular benefits. It enhances serotonin metabolism, dopamine signaling, and blood-brain barrier permeability, promoting cognitive function and cardiovascular health.
Key Benefits
- Cognitive Enhancement – Boosts memory, focus, and learning capacity through increased serotonergic activity.
- Reduces Anxiety & Stress – Restores monoamine balance, potentially mitigating SSRI-induced anxiety in neonatal models.
- Supports Vascular Health – Protects cardiac function, preventing ventricular hypertrophy post-myocardial infarction.
- Aids Emotional Regulation – Normalizes stress responses, reducing anxiety caused by maternal deprivation.
- Promotes Neural Recovery – Enhances brain function restoration post-ischemic stroke, supporting neuroprotection.
Reference
Kost NV, Sokolov OIu, Gabaeva MV, Grivennikov IA, Andreeva LA, Miasoedov NF, Zozulia AA. Ingibiruiushchee deĭstvie semaksa i selanka na énkefalindegradiruiushchie fermenty syvorotki krovi cheloveka [Semax and selank inhibit the enkephalin-degrading enzymes from human serum]]. Bioorg Khim. 2001 May-Jun;27(3):180-3. Russian. doi: 10.1023/a:1011373002885. PMID: 11443939. https://pubmed.ncbi.nlm.nih.gov/11443939/
Nataliya Yu. Glazova, Daria M. Manchenko, Maria A. Volodina, Svetlana A. Merchieva, Ludmila A. Andreeva, Vladimir S. Kudrin, Nikolai F. Myasoedov, Natalia G. Levitskaya, Semax, synthetic ACTH(4–10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats, Neuropeptides, Volume 86, 2021, 102114, ISSN 0143-4179. https://doi.org/10.1016/j.npep.2020.102114
T. Kolomin et al., A New Generation of Drugs: Synthetic Peptides based on Natural Regulatory peptides. Neuroscience & Medicine, 2013, 223-252. Published Online December 2013. http://dx.doi.org/10.4236/nm.2013.44035