Pinealon

Strictly for research purposes

Pinealon is a synthetic tripeptide — that means it’s a very short chain of three amino acids linked by peptide bonds. Its well-accepted chemical sequence is:

L-Glutamic acid — L-Aspartic acid — L-Arginine (often abbreviated Glu-Asp-Arg or EDR peptide) 

Molecular specifics:

• Chemical formula: C₁₅H₂₆N₆O₈ 

• Structure: A linear peptide made of two acidic (Glu, Asp) and one basic (Arg) amino acids, giving it a mixed charge and high water solubility 

Because of its small size (~390 Daltons) and polarity, Pinealon can cross biological membranes in cell-based models and is studied for potential intracellular activity .

Benefits and research use:

Research into Pinealon focuses on several molecular and cellular processes:

1. Gene Expression / Nuclear Interaction

• Experimental studies suggest this peptide might interact with DNA or chromatin-associated proteins, influencing gene expression in neural cells under certain conditions  .

2. Antioxidant / Redox Effects

• In cell models, Pinealon has been shown to suppress reactive oxygen species (ROS) accumulation, which can stabilize oxidative stress pathways and promote cell survival under stress  .

3. Neuroprotection & Cell Survival

• Laboratory evidence indicates it might reduce apoptosis (programmed cell death) and enhance neuronal cell viability after oxidative stress or metabolic challenges  .

4. Mitochondrial & Metabolic Support

• Some research frameworks examine effects on mitochondrial membrane potential or cellular energy pathways, although these are primarily descriptive in vitro readouts  .

5. Circadian & Neuroendocrine Pathways (less well-established)

• Some exploratory contexts associate Pinealon with regulation of sleep-wake cycles and factors like melatonin, though strong mechanistic evidence in humans is limited  .

Preclinical Evidence & Biological Findings

Most documented research on Pinealon comes from non-clinical models (cell culture and animals):

Neuroprotective Effects

• In rat studies of prenatal stress (hyperhomocysteinemia), exposure to Pinealon improved offspring cognitive outcomes and enhanced neuron resistance to oxidative damage  .

Cognitive Endpoints

• Other animal experiments suggest improved memory, reduced neuronal cell death, and enhanced brain-related function after peptide administration  .

Anti-aging Observations

• Some Russian studies categorize Pinealon as a “bioregulator” with potential geroprotective activity, meaning it may support physiological resistance to aging-related challenges in models of central nervous system dysfunction  .

Potential Benefits Studied Research 

Experimental and preliminary data suggest Pinealon may be associated with:

• Neuroprotection — less oxidative stress, enhanced neuronal survival in cell and animal models 

• Improved cognitive function — in rodent behavioral tests in select studies 

• Reduced cellular aging markers — proposed in gerontological research contexts 

• Potential circadian regulation — hypothesized linkage to pineal gland function and sleep-related processes 

 It’s important to stress that these outcomes are from experimental, preclinical, or limited human contexts in the scientific literature. Large-scale clinical trials in humans to confirm effectiveness, safety, dosing, and therapeutic indications are not well established.