NMN

NMN: Nicotinamide Mononucleotide

Molecular Formula: C₁₁H₁₅N₂O₈P
Molecular Weight: ~334.22 g/mol

MN is a precursor to NAD⁺ (nicotinamide adenine dinucleotide)—a critical coenzyme involved in:

• Energy metabolism (mitochondrial function)

• DNA repair (via PARPs)

• Gene expression (via sirtuins like SIRT1)

• Cell survival under stress

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NMN → NAD⁺ pathway:

• NMN is converted into NAD⁺ by the enzyme NMNAT (nicotinamide mononucleotide adenylyltransferase).

• NAD⁺ then acts as a coenzyme in numerous redox and enzymatic reactions essential for cellular health, longevity, and metabolism.

Key Benefits of NMN Supplementation

 1. Supports Healthy Aging

• Boosts NAD⁺ levels that decline with age

• Activates sirtuins (SIRT1–SIRT7), which regulate longevity, inflammation, and circadian rhythms

2.  Enhances Energy & Mitochondrial Function

• NAD⁺ is critical for mitochondrial ATP production

• May improve endurance, fatigue resistance, and metabolic function

3. Neuroprotection

• NAD⁺ is used by neurons to resist oxidative stress

• Supports cognition, memory, and may reduce risk of age-related cognitive decline

4. Cardiovascular Health

• Promotes endothelial function and blood flow

• NAD⁺ helps repair damaged heart and vascular tissues

 5. DNA Repair & Cell Survival

• NAD⁺ fuels PARP enzymes, key to repairing DNA breaks caused by UV and oxidative stress

• Shown to improve insulin sensitivity and support glucose metabolism in preclinical studies

6. Metabolic and Insulin Sensitivit