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MOTS-C
C$54.99
For Research Purposes Only
MOTS-c Peptide
Scientific Overview and benefits
MOTS-c, a mitochondria-derived 16-amino-acid peptide, exhibits both cell-specific and hormonal functions, modulating AMP-activated protein kinase (AMPK) pathways to regulate metabolic stress responses and gene expression. It has been classified as a mitokine, influencing systemic metabolism through intracellular signaling.
Mechanism of Action
- Muscle Metabolism: Enhances insulin sensitivity, stimulates glucose transporters, and optimizes skeletal muscle adaptation via AMPK activation.
- Fat Cell Regulation: Modifies gene expression through mitonuclear communication, impacting antioxidant response elements (ARE) and metabolic pathways linked to glucose uptake and lipid utilization.
- Bone Formation: Regulates TGF-β/SMAD signaling, promoting osteogenic differentiation and bone density enhancement.
- Cardiovascular Influence: Correlates with endothelial function, potentially improving vascular reactivity via AMPK-mediated mechanisms.
- Cell Longevity: Interacts with aging regulators (NAD+, sirtuins) and exhibits a potential role in lifespan modulation.
Quantity
Chemical Properties
- Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
- Molecular Weight: 2174.64 g/mol
Scientific Insight
Preclinical Studies:
Preclinical studies suggest MOTS-c plays a pivotal role in metabolic homeostasis, tissue regeneration, and aging regulation, marking it as a promising target for further therapeutic research
Refrences :
Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015 Mar 3;21(3):443-54. doi: 10.1016/j.cmet.2015.02.009. PMID: 25738459; PMCID: PMC4350682.
Lu H, Wei M, Zhai Y, Li Q, Ye Z, Wang L, Luo W, Chen J, Lu Z. MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction. J Mol Med (Berl). 2019 Apr;97(4):473-485. doi: 10.1007/s00109-018-01738-w. Epub 2019 Feb 6. PMID: 30725119. https://pubmed.ncbi.nlm.nih.gov/30725119/
Reynolds JC, Lai RW, Woodhead JST, Joly JH, Mitchell CJ, Cameron-Smith D, Lu R, Cohen P, Graham NA, Benayoun BA, Merry TL, Lee C. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun. 2021 Jan 20;12(1):470. https://pubmed.ncbi.nlm.nih.gov/33473109/
Kim KH, Son JM, Benayoun BA, Lee C. The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress. Cell Metab. 2018 Sep 4;28(3):516-524.e7. doi: 10.1016/j.cmet.2018.06.008. Epub 2018 Jul 5. PMID: 29983246; PMCID: PMC6185997. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185997/
Hu BT, Chen WZ. MOTS-c improves osteoporosis by promoting osteogenic differentiation of bone marrow mesenchymal stem cells via TGF-β/Smad pathway. Eur Rev Med Pharmacol Sci. 2018 Nov;22(21):7156-7163. doi: 10.26355/eurrev_201811_16247. PMID: 30468456. https://pubmed.ncbi.nlm.nih.gov/30468456/
MOTS-C peptide is available for research and laboratory purposes only. Please review and adhere to our Terms and Conditions before ordering.
