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DSIP
C$37.99
For Research Purpose Only
DSIP (Delta Sleep-Inducing Peptide)
Delta Sleep-Inducing Peptide (DSIP) is a nonapeptide identified in the central nervous system, initially studied for its potential role in sleep regulation. DSIP is hypothesized to influence neuronal activity and neurotransmitter balance, with suggested interactions involving glutamatergic (NMDA), GABAergic, opioid, and adrenergic receptors. Despite ongoing research, the precise mechanisms remain under investigation.
Mechanisms of Action
- NMDA & GABA Receptors: DSIP may enhance inhibitory GABAergic activity while reducing excitatory NMDA receptor signaling, contributing to sleep modulation.
- Opioid Receptors: Potential indirect interaction with opioid receptors, which may influence sleep cycles and withdrawal symptoms.
- Alpha 1-Adrenergic Receptor: Possible involvement in stress modulation via adrenergic pathways in the pineal gland.
Potential Benefits (as suggested by preclinical studies)
- Supports sleep onset and quality improvement
- May aid in stress tolerance and adaptation
- Suggested to have analgesic properties
- Possible role in withdrawal mitigation
Quantity
Molecular Makeup
Molecular Formula: C35H48N10O15
Molecular Weight: 848.82 g/mol
Other Known Titles: DSIP nonapeptide; emideltide
Research Insights
Delta Sleep-Inducing Peptide (DSIP) – Research Overview
Sleep Regulation
Preclinical studies suggest DSIP may enhance total sleep and slow-wave sleep (SWS), a deep sleep phase associated with restoration. Feline models exhibited increased sleep duration post-administration, with effects sustained for several hours. Clinical trials indicate DSIP may accelerate sleep onset and improve sleep efficiency.
Endocrine Modulation: DSIP is proposed to interact with hormones such as luteinizing hormone (LH) and growth hormone (GH), potentially contributing to sleep-related endocrine regulation. Murine studies observed elevated LH levels post-DSIP exposure, with GH secretion influenced by dopaminergic pathways.
Stress Response: Experiments on murine models suggest DSIP may modulate stress markers such as substance P, beta-endorphins, and corticosterone. DSIP exposure correlated with decreased corticosterone levels, potentially indicating stress-mitigating effects via the opioidergic system.
Longevity & Cellular Protection: Murine studies propose DSIP may reduce chromosomal aberrations in bone marrow and enhance lifespan. Additionally, DSIP may possess antioxidant properties, inhibiting lipid peroxidation and stimulating enzymatic defense mechanisms, potentially mitigating age-related oxidative stress.
Potential Benefits (Based on Preclinical Findings)
- Supports deep sleep & overall sleep efficiency
- May influence hormonal balance (LH & GH secretion)
- Possible stress-buffering effects via neurotransmitter interactions
- Suggested antioxidative & lifespan-extending properties
Reviews
I added DSIP to my stack hoping for better rest, and it exceeded expectations. Highly recommended.